Haworth, Brian T. Sutch, Rebecca M. Romero Objectives To evaluate faculty-led discussion meetings (with about eight students) conducted face-to-face (in-class) or by synchronous, real-time videoconference (online), in a biopharmaceutics course taught in a facilitated problem-based learning (PBL) format. Methods Three methods were used to compare in-class versus online discussion sessions for two semesters. The first method involved three parameters that measured the quality of interactions between faculty (facilitator) and student (Fc–St), participation of students in the discussions (Par), and student–student interactions (St–St). The second method assessed student’s perceptions of the discussions with surveys. The third method mapped the interactions (a sociogram) between faculty (facilitator) and students in a discussion. Results There were significantly lower scores for Par and St–St (P < 0.05)>
Biological goals and you can pharmacology from curcumin
Book ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Yards. Romero, Ian S Haworth Curcumin ‘s the significant element of the new yellow dye of turmeric, a keen Indian spruce that’s extracted from the new rhizome of the tropical bush Curcuma longa, and this belongs to the Zingiberaceae nearest and dearest. Within section, we discuss the pharmacological activities off curcumin and you may explore the molecular bases of these items. I upcoming opinion the brand new confirmed and you will potential scientific spends of curcumin. Curcumin is famous usually because a curative broker, however, its process off action is actually outlined. This new pharmacological ramifications of curcumin be seemingly caused by a great synergism of networking sites off weak biochemical affairs having multiple biological targets in the interrelated signaling routes. Such aim become nutrients eg cyclooxygenase, lipoxygenase and you may proteins kinases, and you may transcription points such as for instance NF-?B, STAT and Nrf2. Modulation of those particles impacts downstream affectors that produce brand new antiinflammatory, antioxidant, chemopreventive, anticancer, and you can antimicrobial affairs from curcumin. This type of consequences was in fact checked for the medical examples out of curcumin to possess soreness and you may inflammatory problems, cancer, Alzheimer disease, cardio problems, and you may diabetes. This new samples used variable amounts off curcuminwith other wavelengths and you may cycle, for the general conclusion you to definitely higher amounts regarding curcumin within amount of grams must see healing consequences. Read more
Curcumin: Synthesis, Growing Role when you look at the Serious pain Government and Fitness Ramifications
Book Section Types of plant-derived pharmaceuticals having get to be the attention from proceeded and you may great browse and you can creativity attention possess, thus far, been some scarce. Immediately following a long period, the past 2 decades was in fact characterized by an effective 100-flex rise in how many medical stuff had written annually one is out-of benefits on the accessibility curcumin during the biomedicine. Find out more
Framework, synthesis and you can physiological facts away from curcumin prodrugs
Book ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Meters. Romero, Ian S Haworth Curcumin has some possible pharmacological effects that will keeps healing software in several disease says, because the discussed in detail in the previous part. However, the potential systematic efficacy regarding curcumin is limited of the its physicochemical services from terrible drinking water solubility and you will instability, which result in reduced bioavailability. Prodrugs out-of curcumin render an easy way to improvement of the biopharmaceutical and you will pharmacokinetic characteristics, that will enable it to be exploitation of the pharmacological aftereffects of curcumin. Contained in this part, i first remark the newest physicochemical and you will pharmacokinetics from curcumin. We up coming determine the appearance of curcumin prodrugs which have increased h2o solubility and you de tio länder med de vackraste kvinnorna i världen can enhanced chemical stability which might be translated back into totally free curcumin on bioactivation during the vivo. I stress previous profits in this area, that have a focus on the design, synthesis and you can research of prodrugs according to promoieties including amino acids, fatty acids, nucleic acids, dicarboxylic acids, and you may polymeric material including hyaluronic acidic and you may polyethylene glycol. It section provides the reason for optimisation of the physicochemical and you will biopharmaceutical properties and also the physical products away from curcumin prodrugs, towards goal playing with of those curcumin types inside systematic applications. Find out more
